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Cancer Preventive Drug Development


This area includes development and testing of drugs, vaccines, and natural products individually and/or in combination for primary and secondary cancer prevention. Drug development is an arduous and multistep process. CCPDD research focuses on developing chemopreventive agents and/or biologics to target the precursor lesions of major epithelial cancers and their progression to metastatic invasive cancers. 

Thus, CCPDD research involves identifying potential drug targets, developing small molecule inhibitors and biologics using high through-put screening assays, establishing the optimal drug doses & preventive efficacy towards major organ site cancers, and assessing their pharmacokinetics (PK), pharmacodynamics (PD), and toxicities in preclinical models before considering them for Phase 0, I, or II clinical trials.

Testing chemopreventive and/or other biologics in pre-clinical studies will determine whether or not the candidate agents are safe and effective enough to be advanced to clinical trials in high-risk individuals. A comprehensive team of expertise and state-of-the-art research facilities exist at the CCPDD and SCC to undertake these cancer drug developmental activities.

Contact & Links


Contact Information

Center for Cancer Prevention and Drug Development Clinic
975 NE 10th St., BRC 1203
Oklahoma City, OK 73104
P: (405) 271-3224
F: (405) 271-3225


Chinthalapally V. Rao, PhD
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Collaborating Centers for NCI Prevention Cancer Drug / Biomarkers Development

Lombardi Cancer Center
MD Anderson Cancer Center
New York University Medical Center
Penn State Cancer Institute
Rutgers, the State University of New Jersey
The State University of New York, Stony Brook
University of Alabama
University of Alabama
University of Washington

Resources & Facilities

Various laboratories in the Center offer research experience and training opportunities to postdoctoral and clinical fellows, residents, and students ranging from high school through graduate levels.

Learn more about research and training opportunities >

Resources & Facilities