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Research

Cancer Functional Genomics Core

 

Gene expression variability across the genome has significant impact on understanding the progress and prognosis of cancer. The Cancer Functional Genomics Core at the Stephenson Cancer Center offers cutting-edge technology that can provide extremely accurate and reliable expression data to support drug discovery research. The versatile Agilent SureScan Microarray Scanner system provides the ability to scan genome-wide microarray profiles. 

For quality assessment of purified RNA and DNA, there are two instruments that include the Biorad Experion™ Automated Electrophoresis Station and Agilent 2100 Bioanalyzer. The Biorad CFX96™ Touch Real-Time PCR Detection System provides highly-reliable quantitative individual gene transcription profiling. Bio-Rad QX100 Droplet Digital PCR is useful to detect the absolute copy number of the genes. 

Functional analysis of proteins using biochemical assay can be evaluated with the Perkin Elmer EnVision® Multilabel Reader. An ultimate high-throughput high-content imaging instrument, Operetta from Perkin Elmer can provide high resolution images for screening drugs under live and fixed cell context. Live cell metabolic changes with respect to oxygen consumption and pH change due to respiration can be determined using Xfe 96 extracellular flux analyzer exclusively from Seahorse.

Services

Array Scanning and Quantification
Reverse Proteomics
Array Real-Time PCR
Multimodal Assay Screening
DNA / RNA / Protein Purity Analysis on a Chip
High-content Drug Screening
Metabolic Analysis of Live Cells
Absolute Allele Copy Number Determination
Clonogenic colony and spheroid counting

Contacts & Links

Contact Information

Muralidharan Jayaraman, PhD
Director of Research Core Operations
P: (405) 271-6890
E: muralidharan-jayaraman@ouhsc.edu

Core Hours

Monday through Friday
8 am to 5 pm

Access the Core

The Stephenson Cancer Center uses iLab for online scheduling for shared resources.

Use iLab to access this core >

Rates and Billing

For rates and billing information, please contact the Director of Research Core Operations.

Usage Acknowledgement

If research supported by the Stephenson Cancer Center core facilities results in a publication or news release, please acknowledge this support in your manuscript. Following publication, please send us one of your reprints for our records.